Miscanthus has been reported growing, and producing high or reasonable yields on a wide range of soils, from sands to high organic matter soils. It is also tolerant of a wide range of pH, but the optimum is between pH 5.5 and 7.5. Miscanthus is harvested in the winter or early spring and therefore it is essential that the site does not get excessively waterlogged during this period, as this may limit accessibility for harvesting machinery and cause damage to the soil structure. Growing Miscanthus on heavy clay soils in certain circumstances should therefore be avoided.

Weed control at establishment is very important. Labelled herbicide choices are limited making a clean field at planting critical. Planting an herbicide tolerant crop in the previous year and using a cover crop prior to Miscanthus establishment can reduce weed pressure. As with other vegetatively propagated crops, adequate soil moisture at planting greatly favours establishment success. Establishment success may be limited by death of plants in the first winter after planting.